Nocturia affects
millions in the U.S.1

More than 40 million adults
(22% of the population)
experience ≥2 voids a night1,2

Nocturia (≥2 nighttime voids) affects adults of all ages

In a survey of over 9,000 adults1:

Incidence ranged from 11-48% in men
aged 20 to 65+

Incidence ranged from 18-43% in women
aged 20 to 65+

Two or more nocturnia episodes a night disrupts sleep, since patients need to wake up frequently to void.3

To identify the true cause of nocturia,
look beyond the expected

Possible cause of Nocturia


Enlarged prostate, also known as benign prostatic hyperplasia, or BPH


Many believe overactive bladder (OAB) or benign
prostatic hyperplasia (BPH) are responsible4

The true cause is often nocturnal polyuria (NP)

NP is found in up to 88% of patients with nocturia5

Nocturnal polyuria (NP) defined

With NP, the kidneys produce too much urine at night, which can lead to frequent nighttime bathroom visits

In NP, the kidneys produce
too much urine at night6

When the volume of nighttime urine production exceeds6


of daily urine total
in patients <65


of daily urine total
in patients >65

NP often coexists with OAB and BPH

>60% MEN

have both OAB and
nocturnal polyuria7,8

>85% MEN

have both BPH and
nocturnal polyuria9,11

In the treatment of nocturia, the bladder and prostate
aren’t always the source of the problem

Lower Urinary Tract Symptoms (LUTS) medications may not work
because they don’t treat nocturnal polyuria, a disease that affects the kidneys10

References: 1. Vaughan CP, Fung CH, Huang AJ, et al. Differences in the association of nocturia and functional outcomes of sleep by age and gender: a cross-sectional, population-based study. Clin Ther. 2016;38(11):2386-2393. 2. Henry J Kaiser Family Foundation. residents. Accessed June 13, 2018. 3. Oelke M, De Watcher S, Drake MJ, et al. A practical approach to the management of nocturia. Int J Clin Pract. 2017;71(11):e13027:1‐11. 4. Weiss JP. Nocturia: focus on etiology and consequences. Rev Urol. 2012;14(3-4):48-55. 5. Weiss JP, van Kerrebroeck PE, Klein BM, et al. Excessive nocturnal urine production is a major contributing factor to the etiology of nocturia. J Urol. 2011;186(4):1358-1363. 6. Fine ND, Weiss JP, Wein AJ. Nocturia: consequences, classification, and management. F1000Res. 2017;6(F1000 Faculty Rev):1‐7.doi:10.12688/f1000research.11979.1:1‐7. 7. Brubaker L, FitzGerald MP. Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms. Int Urogynecol J Pelvic Floor Dysfunct. 2007;18(7):737-741. 8. Rovner ES, Raymond K, Andruczyk E, et al. Low-dose desmopressin and tolterodine combination therapy for treating nocturia in women with overactive bladder: a double-blind, randomized, controlled study. Low Urin Tract Symptoms. 2017. Epub:1‐11. doi:10:1111/luts.12169. 9. Singam P, Hong GE, Ho C, et al. Nocturia in patients with benign prostatic hyperplasia: evaluating the significance of ageing, co-morbid illnesses, lifestyle and medical therapy in treatment outcome in real life practice. Aging Male. 2015;18(2):112-117. 10. Weiss JP, Blaivas JG, Bliwise DL, et al. The evaluation and treatment of nocturia: a consensus statement. BJU Int. 2011;108(1):6-21. 11. Yoong et al. Prevalence of Nocturnal Polyuria in Patients With Benign Prostatic Hyperplasia Med J Malaysia Vol 60 No 3 August 2005: 294-296.